A targeted mode of action

How does Xiapex work?

Xiapex contains collagenase clostridium histolyticum (CCH), which is produced by fermentation of the bacterium clostridium histolyticum. CCH is a proteinase that hydrolyses the triple-helix of collagen under physiological conditions, and therefore can be effective in lysing the collagen deposits seen in Peyronie’s disease. Xiapex acts locally and does not require systemic exposure.1-3

mode of action



  1. French MF et al. Biochemistry. 1987;26:681-687.
  2. Lecroisey A, Keil B. Biochem J. 1979;179:53-58.
  3. Lee H, et al. Mol Biol Cell. 2006;17:4812-4826.